Effect of ammonia in cigarette tobacco on nicotine absorption in human smokers
Effect of ammonia in cigarette tobacco on nicotine absorption in human smokers
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DOI：
10.1016/j.fct.2011.09.037
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发表时间：
2011-12-01
影响因子：
4.3
通讯作者：
Opperhuizen, Antoon
中科院分区：
文献类型：
--
作者：
van Amsterdam, Jan;Sleijffers, Annemarie;Opperhuizen, Antoon
氨作为烟草添加剂的作用一直是科学争论的主题。有人认为，氨通过增加游离尼古丁的比例，增加了吸烟者对尼古丁的吸收。由于香烟中添加了氨，吸烟者暴露在体内尼古丁剂量较高的环境中，并对产品更加上瘾。在两种情况下，吸食了品牌1或品牌2的商业香烟后，对血液中尼古丁的吸收进行了测量，这两种香烟的铵盐含量相差3.8倍。51名经常吸烟的人使用标准吸烟法(吸6口烟，吸30秒间隔，呼出前7次S屏气)，抽品牌1(卡巴列罗柔滑香精；每克烟草0.89毫克铵)和品牌2(高卢斯布鲁内斯；每克烟草3.43毫克铵)。在吸烟期间和吸烟后分别监测烟雾量和心血管参数。对两个品牌在吸烟后一段时间内采集的血液样本中的血清尼古丁水平的测量表明，两个品牌之间吸收的尼古丁总量没有差异。目前的结果表明，吸烟的烟草含有较高数量的烟草添加剂铵不会增加吸烟者体内尼古丁的吸收。(C)2011爱思唯尔有限公司。保留所有权利。
The function of ammonia as tobacco additive is subject of scientific debate. It is argued that ammonia, by increasing the proportion of free nicotine, increases the absorption of nicotine in smokers. As a result of the addition of ammonia to cigarettes, smokers get exposed to higher internal nicotine doses and become more addicted to the product. On two occasions, the nicotine absorption in blood was measured after smoking a commercial cigarette of either brand 1 or brand 2, which differed 3.8-fold in ammonium salt content. Using a standardized smoking regime (six puffs, 30s puff interval, 7 s breath hold before exhalation), 51 regular smokers smoked brand 1 (Caballero Smooth Flavor; 0.89 mg ammonium per gram tobacco) and brand 2 (Gauloise Brunes; 3.43 mg ammonium per gram tobacco). Puff volumes and cardiovascular parameters were monitored during and following smoking, respectively. Measurement of serum nicotine level in the blood samples collected over time following smoking of the two brands, showed that total amount of nicotine absorbed did not differ between the two brands. Present results demonstrate that smoking tobacco containing a higher amount of the tobacco additive ammonium does not increase the absorption of nicotine in the smoker's body. (C) 2011 Elsevier Ltd. All rights reserved.