Time-course of changes in the social interaction test of anxiety following acute and chronic administration of nicotine
Time-course of changes in the social interaction test of anxiety following acute and chronic administration of nicotine
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DOI：
10.1097/00008877-199911000-00016
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发表时间：
1999-11-01
影响因子：
1.6
通讯作者：
File, SE
中科院分区：
文献类型：
--
作者：
Irvine, EE;Cheeta, S;File, SE
这些实验的目的是探索尼古丁对焦虑的影响取决于给药后的时间和治疗持续时间的假设。在焦虑的社会互动测试中，当注射后5分钟对大鼠进行测试时，急性尼古丁给药（0.1 mg/kg，皮下注射）减少了社会互动，但当注射后30分钟进行测试时，增加了社会互动。注射后1小时，社会互动也减少，但水平在3至30小时之间恢复至基线水平。由于这些变化与自主活动的任何变化无关，因此尼古丁似乎在注射后的不同时间具有致焦虑和抗焦虑作用。第二次尼古丁注射后30分钟也观察到抗焦虑作用，注射后5分钟观察到的致焦虑作用在尼古丁给药4天后仍然存在。然而，在尼古丁处理7天后，观察到对这两种作用的耐受性。当大鼠在尼古丁治疗7或14天的最后一天后72小时进行测试时，观察到致焦虑戒断反应。因此，对抗机制可能是抗焦虑作用耐受性的基础，而目前还没有证据表明这种类型的机制介导对致焦虑作用的耐受性。(C)1999年利平科特威廉姆斯&威尔金斯。
The purpose of these experiments was to explore the hypothesis that the effects of nicotine on anxiety depend on the time since administration and the duration of treatment. In the social interaction test of anxiety, acute nicotine administration (0.1 mg/kg, subcutaneously) decreased social interaction when rats were tested 5 min after injection, but increased it when they were tested 30 min after injection. Social interaction was also decreased Ih post-injection, but levels returned to baseline between 3 and 30 h. As these changes were independent of any changes in locomotor activity, nicotine seemed to be having both anxiogenic and anxiolytic effects at different times after injection. An anxiolytic effect was also observed 30 min after the second nicotine injection, and the anxiogenic effect observed 5 min after injection remained after 4 days of nicotine administration. However, after 7 days of nicotine treatment, tolerance was observed to both these effects. When rats were tested 72 h after the last of 7 or 14 days of nicotine treatment, an anxiogenic withdrawal response was observed. Thus, an oppositional mechanism may underlie tolerance to the anxiolytic effects, whereas there is as yet no evidence for this type of mechanism mediating tolerance to the anxiogenic effects. (C) 1999 Lippincott Williams & Wilkins.