Systematic Analysis of Wide-Field Fundus Autofluorescence (FAF) Imaging in Posterior Uveitis
Systematic Analysis of Wide-Field Fundus Autofluorescence (FAF) Imaging in Posterior Uveitis
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DOI：
10.3109/02713683.2013.834938
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发表时间：
2014-02-01
影响因子：
2
通讯作者：
Neubauer, Aljoscha
中科院分区：
文献类型：
--
作者：
Reznicek, Lukas;Seidensticker, Florian;Neubauer, Aljoscha
目的：目的：评价宽视野眼底自发荧光（FAF）在葡萄膜炎伴视网膜或脉络膜视网膜受累患者中的应用。进行最佳矫正视力、全面临床检查、宽视野绿光FAF和Optomap SLO复合彩色、绿色和红色激光分离眼底成像。在一项系统分析中，评价了感染性和非感染性葡萄膜炎研究眼的中央和外周视网膜或脉络膜视网膜改变、瘢痕和浸润的数量、范围和边缘。结果：78只患眼中，9只诊断为感染性葡萄膜炎，69只诊断为非感染性葡萄膜炎。6例感染性葡萄膜炎患者的周边眼底改变，而69例非感染性葡萄膜炎患者中有48例发生周边眼底改变。在33例（感染性与非感染性：4例与29例）病例中，宽视野FAF图像显示了更多的视网膜或脉络膜视网膜改变或病理，其分界线比宽视野复合彩色眼底成像更远。69个非感染性研究的眼睛中有11个被诊断为血管炎，可以更精确地评价与宽场FAF比宽场复合彩色，绿色或红色光过滤fundus imaging.Conclusions：非侵入性宽场FAF检测更多的视网膜或脉络膜视网膜参与后葡萄膜炎患者比彩色成像，从而是有用的葡萄膜炎患者的诊断和随访。
Purpose: To evaluate wide-field fundus autofluorescence (FAF) in patients with uveitis with retinal or chorioretinal involvement.Materials and methods: We included 78 study eyes in this prospective study. Best-corrected visual acuity, a full clinical examination, wide-field green-light FAF and composite color, green and red laser separation fundus imaging with Optomap SLO were performed. In a systematic analysis, the number, extension and margins of central and peripheral retinal or chorioretinal alterations, scars and infiltrates in infectious and non-infectious uveitic study eyes were evaluated. Wide-field FAF and color fundus imaging results were compared regarding their diagnostic properties.Results: Nine out of 78 study eyes were diagnosed with infectious, 69 cases with non-infectious uveitis. Six infectious uveitic study eyes had changes of the peripheral fundus compared with 48 of 69 non-infectious uveitic eyes. In 33 (infectious versus non-infectious: 4 versus 29) cases, wide-field FAF images revealed more retinal or chorioretinal alterations or pathologies with a farther extended demarcation than wide-field composite color fundus imaging. Eleven out of 69 non-infectious study eyes were diagnosed with vasculitis which could be more precisely evaluated with wide-field FAF than wide-field composite color, green or red light filtered fundus imaging.Conclusions: Non-invasive wide-field FAF detects more retinal or chorioretinal involvement in patients with posterior uveitis than seen in color imaging and thus is useful in diagnosis and follow-up of uveitic patients.