Uncomplicated type 1 diabetes is associated with increased asymmetric dimethylarginine concentrations
Uncomplicated type 1 diabetes is associated with increased asymmetric dimethylarginine concentrations
复制标题
DOI：
10.1210/jc.2006-2643
复制
发表时间：
2007-05-01
影响因子：
5.8
通讯作者：
Toruner, Fusun B.
中科院分区：
文献类型：
--
作者：
Altinova, Alev E.;Arslan, Metin;Toruner, Fusun B.
背景：不对称二甲基精氨酸（ADMA）最近被认为是心血管疾病的独立危险标志物，但研究1型糖尿病（DM）中ADMA水平的研究很少。目的：评估无并发症1型糖尿病患者和对照组血浆ADMA、l -精氨酸浓度和l -精氨酸/ ADMA比值。设计和研究对象：40例无血管并发症临床证据的1型糖尿病患者和35名健康对照者纳入研究。结果：糖尿病组血浆ADMA浓度高于对照组（2.6 +/- 1.9 vs. 1.7 +/- 0.7 mu mol/l, P < 0.01）， l -精氨酸水平低于对照组（79.3 +/- 22.6 vs. 89.6 +/- 19.4 mu mol/l, P < 0.05）。糖尿病组l -精氨酸/ ADMA比值也较低（38.7 +/- 17.1 vs. 62.0 +/- 27.9, P < 0.0001）。在糖尿病患者中，logADMA与体重指数（BMI） （P = 0.01）、空腹血糖（P = 0.006）、低密度脂蛋白胆固醇（LDL-c） （P = 0.01）呈正相关，与高密度脂蛋白胆固醇（P = 0.03）呈负相关。l -精氨酸/ ADMA与BMI （P = 0.004）、空腹血糖（P = 0.02）、LDL-c （P = 0.01）呈负相关，与高密度脂蛋白胆固醇呈正相关（P = 0.04）。在对照组中，logADMA和l -精氨酸/ ADMA比值与BMI和LDL-c相关（P < 0.05）。在回归分析中，BMI预测ADMA水平的方差为15% （P = 0.02）。结论：我们证明，即使在1型糖尿病发生血管并发症之前，ADMA增加，l -精氨酸与ADMA之比降低。
Context: Asymmetric dimethylarginine ( ADMA) has recently emerged as an independent risk marker for cardiovascular disease, but studies investigating the ADMA levels in type 1 diabetes mellitus ( DM) are scarce.Objective: We aimed to evaluate plasma ADMA, L-arginine concentrations, and L-arginine to ADMA ratio in uncomplicated type 1 diabetic patients and controls.Design and Subjects: Forty patients with type 1 DM who did not have clinical evidence of vascular complications and 35 healthy controls were included in the study.Results: Plasma ADMA concentrations were higher ( 2.6 +/- 1.9 vs. 1.7 +/- 0.7 mu mol/liter, P < 0.01), and L-arginine levels were lower ( 79.3 +/- 22.6 vs. 89.6 +/- 19.4 mu mol/liter, P < 0.05) in the diabetic group, compared with controls. The L-arginine to ADMA ratio was also lower in the diabetic group ( 38.7 +/- 17.1 vs. 62.0 +/- 27.9, P < 0.0001). In diabetic patients, logADMA correlated positively with body mass index ( BMI) ( P = 0.01), fasting blood glucose ( P = 0.006), and low-density lipoprotein cholesterol ( LDL-c) ( P = 0.01) and negatively with high-density lipoprotein cholesterol ( P = 0.03). L-Arginine to ADMA ratio correlated negatively with BMI ( P = 0.004), fasting blood glucose ( P = 0.02), and LDL-c ( P = 0.01) and positively with high- density lipoprotein cholesterol ( P = 0.04). In controls, logADMA and L-arginine to ADMA ratio correlated with BMI and LDL-c ( P < 0.05). In regression analysis, BMI predicted 15% variance of ADMA levels ( P = 0.02).Conclusions: We demonstrated that ADMA increases and L-arginine to ADMA ratio decreases, even before the development of vascular complications in type 1 DM.