Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines
Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines
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DOI：
10.1016/j.tube.2003.08.006
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发表时间：
2004-01-01
期刊：
影响因子：
3.2
通讯作者：
Mizrahi, V
中科院分区：
文献类型：
--
作者：
Kana, BD;Mizrahi, V
允许以定向或随机方式诱变分枝杆菌基因组的遗传系统通过允许确定和验证潜在靶点，为开发诊断、预防和治疗结核病的新工具提供了手段。在这篇综述中，我们重点介绍了分枝杆菌领域的关键历史发展。遗传学，它已经产生了现在手中的强大的遗传工具库，并提供了例子说明它们在探索分枝杆菌新陈代谢的特定方面的用途。(C)2003爱思唯尔有限公司。保留所有权利。
Genetic systems that allow mycobacterial genomes to be mutagenized in a targeted or random fashion have provided the means for developing new tools for the diagnosis, prevention and treatment of tuberculosis by allowing potential targets to be identified and validated. In this review, we highlight key historical developments in the field of mycobacterial. genetics, which have yielded the powerful repertoire of genetic tools that are now in hand and provide examples that illustrate their use in exploring specific aspects of mycobacterial metabolism. (C) 2003 Elsevier Ltd. All rights reserved.