Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery
Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery
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DOI：
10.1021/acs.jpcb.2c06751
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发表时间：
2023-02
期刊：
影响因子：
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通讯作者：
Vijay Bhooshan Kumar;Busra Ozguney;A-M. Vlachou;Yu Chen;E. Gazit;P. Tamamis
中科院分区：
文献类型：
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作者：
Vijay Bhooshan Kumar;Busra Ozguney;A-M. Vlachou;Yu Chen;E. Gazit;P. Tamamis
新型抗癌药物纳米载体的设计在癌症治疗学的框架中至关重要。纳米材料作为癌症药物递送系统越来越受到关注。自组装肽构成了一类新兴的高度有吸引力的纳米材料，在药物递送中具有非常有前途的应用，因为它们可以用于促进药物释放和/或稳定性，同时减少副作用。在这里，我们提供了一个角度对肽自组装纳米载体的癌症药物输送和突出的方面，金属配位，结构稳定，环化，以及极简主义。我们回顾了纳米医学设计标准中的特殊挑战，最后，提供了未来的观点，通过自组装肽系统来解决部分挑战。我们认为，这种系统的内在优势，沿着越来越多的进展，在计算和实验方法的研究和设计，可能会导致新的类的单一或多组分系统，将这些材料的癌症药物输送。
The design of novel cancer drug nanocarriers is critical in the framework of cancer therapeutics. Nanomaterials are gaining increased interest as cancer drug delivery systems. Self-assembling peptides constitute an emerging novel class of highly attractive nanomaterials with highly promising applications in drug delivery, as they can be used to facilitate drug release and/or stability while reducing side effects. Here, we provide a perspective on peptide self-assembled nanocarriers for cancer drug delivery and highlight the aspects of metal coordination, structure stabilization, and cyclization, as well as minimalism. We review particular challenges in nanomedicine design criteria and, finally, provide future perspectives on addressing a portion of the challenges via self-assembling peptide systems. We consider that the intrinsic advantages of such systems, along with the increasing progress in computational and experimental approaches for their study and design, could possibly lead to novel classes of single or multicomponent systems incorporating such materials for cancer drug delivery.