MIS/AMH in the assessment of cryptorchidism and intersex conditions
MIS/AMH in the assessment of cryptorchidism and intersex conditions
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DOI：
10.1016/j.mce.2003.09.014
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发表时间：
2003-12-15
影响因子：
4.1
通讯作者：
MacLaughlin, DT
中科院分区：
文献类型：
--
作者：
Lee, MM;Misra, M;MacLaughlin, DT
苗勒管抑制物质（MIS），也称为抗苗勒管激素（AMH），在男性性分化期间引起苗勒管退化，并且在性腺中也具有出生后调节作用。血清MIS/AMH具有性腺特异性表达模式，其浓度在儿童中具有性别二态性;因此，血清MIS/AMH的测量有助于评估性腺疾病儿童。在隐睾（未触及性腺）男孩中，血清MIS/AMH与睾丸组织相关。可测量的值预测隐睾，而不可检测的值高度提示无精症。在最小男性化表型女性中，MIS/AMH有助于区分男性化的性腺和非性腺原因。在具有中间性条件的儿童中，MIS/AMH值有助于鉴别诊断：高于正常女性范围的值预测睾丸组织，而检测不到的值则提示睾丸组织缺失。因此，MIS/AMH是有用的描绘性腺病理，并有利于不同的性腺疾病的儿童的鉴别诊断和管理。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Mullerian inhibiting substance (MIS), also known as anti-Mullerian hormone (AMH), causes Mullerian duct involution during male sexual differentiation and also has a postnatal regulatory role in the gonads. Serum MIS/AMH has a gonad specific pattern of expression and its concentrations are sexually dimorphic in children; hence measurement of serum MIS/AMH helps in the evaluation of children with gonadal disorders. In boys with cryptorchidism (non-palpable gonads), serum MIS/AMH correlates with testicular tissue. A measurable value is predictive of undescended testes while an undetectable value is highly suggestive of anorchia. In minimally virilized phenotypic females, MIS/AMH helps differentiate between gonadal and non-gonadal causes of virilization. In children with intersex conditions, MIS/AMH values assist differential diagnosis: a value above the normal female range is predictive of testicular tissue, while an undetectable value is suggestive of absent testicular tissue. Thus, MIS/AMH is useful for delineating gonadal pathology and facilitates the differential diagnosis and management of children with diverse gonadal disorders. (C) 2003 Elsevier Ireland Ltd. All rights reserved.