RELATIONSHIP OF PLASMA-LIPOPROTEIN LP(A) LEVELS TO RACE AND TO APOLIPOPROTEIN-B
RELATIONSHIP OF PLASMA-LIPOPROTEIN LP(A) LEVELS TO RACE AND TO APOLIPOPROTEIN-B
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DOI：
10.1161/01.atv.5.3.265
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
GOTTO, AM
中科院分区：
文献类型：
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作者：
GUYTON, JR;DAHLEN, GH;GOTTO, AM
脂蛋白Lp(a)是血浆脂蛋白的致动脉粥样硬化亚组分，主要在白人人群中研究。采用电免疫法定量测定105名黑人和134名白人健康男女血浆中的Lp(a)。结果与临床变量和血浆脂质水平、其他脂蛋白水平以及放射免疫测定的载脂蛋白（apo） B相关。黑人受试者的Lp(a)水平平均是白人的两倍（P < 0.001）。在黑人群体中，Lp(a)水平呈钟形频率分布，而在白人群体中，Lp(a)的分布呈强烈偏态，在低水平处频率最高。与先前发表的结果相反，本研究中载脂蛋白B水平与Lp(a)的相关性虽弱但显著（白人中r = 0.21, P = 0.001，黑人中r = 0.15, P = 0.02， Kendall秩相关）。回归斜率和方差表明，脂蛋白(a)中的载脂蛋白B可以解释相关性。Lp(a)水平与其他血浆脂蛋白或脂质水平无显著相关性。尽管在[美国德克萨斯州]休斯顿地区的黑人中Lp(a)水平很高，但这些黑人的动脉粥样硬化进展和死亡率并没有显著增加。黑人中Lp(a)的动脉粥样硬化性必须通过其他因素来降低或平衡。在分析动脉粥样硬化风险时应考虑到脂蛋白(a)和载脂蛋白B之间的相关性，但这种相关性不足以质疑脂蛋白(a)和载脂蛋白B作为危险因素的独立性。
Lipoprotein Lp(a) is an atherogenic subfraction of plasma lipoproteins which was studied predominantly in white populations. Lp(a) was quantified by electroimmunoassay in plasma from 105 black and 134 white healthy men and women. Results were correlated with clinical variables and plasma levels of lipids, other lipoproteins, and apolipoprotein (apo) B determined by radioimmunoassay. Black subjects had levels of Lp(a) that averaged twice those of whites (P < 0.001). Among blacks, Lp(a) levels showed a bell-shaped frequency distribution, while among whites the distribution was strongly skewed, with the highest frequencies at low levels. Contrary to previously published results, the apo B levels in this study correlated significantly, though weakly, with Lp(a) (r = 0.21, P = 0.001 among whites and r = 0.15, P = 0.02 among blacks, Kendall rank correlation). The regression slopes and variances suggested that apo B in the Lp(a) lipoprotein could account for the correlation. Lp(a) levels did not correlate significantly with any other plasma lipoprotein or lipid levels. Despite the high levels of Lp(a) among blacks in the Houston [Texas, USA] area, these blacks do not experience greatly increased atherosclerotic progression and mortality. The atherogenicity of Lp(a) in blacks must be decreased or counterbalanced by other factors. The correlation between Lp(a) and apo B should be taken into account when analyzing atherogenic risk, but this correlation is not strong enough to dispute the independence of Lp(a) and apo B as risk factors.