In vitro myelosuppression and immunosuppression by ethanol.
In vitro myelosuppression and immunosuppression by ethanol.
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乙醇的体外骨髓抑制和免疫抑制。
DOI：
10.1172/jci107314
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
V. Herbert
中科院分区：
文献类型：
--
作者：
G. Tisman;V. Herbert
与中毒患者血液中浓度相似的乙醇会抑制植物血凝素或链球菌溶血素 O 诱导的淋巴细胞转化，并抑制软琼脂中骨髓粒细胞集落的生长。尽管存在高浓度的叶酸和其他维生素，但淋巴细胞转化和粒细胞集落生长受到抑制。这些体外研究结果可能与乙醇对骨髓和淋巴组织的体内影响有关。
Concentrations of ethanol similar to those in the blood of intoxicated patients suppressed phytohemagglutinin- or streptolysin O-induced lymphocyte transformation, and inhibited bone marrow granulocyte colony growth in soft agar. Inhibition of lymphocyte transformation and granulocyte colony growth occurred despite the presence of large concentrations of folate and other vitamins. These in vitro findings may relate to in vivo effects of ethanol on myeloid and lymphoid tissue.