(-)-Grandiflorimine, a new dibenzopyrrocoline alkaloid with cholinesterase inhibitory activity from Illigera grandiflora
(-)-Grandiflorimine, a new dibenzopyrrocoline alkaloid with cholinesterase inhibitory activity from Illigera grandiflora
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(-)-Grandiflorimine，一种来自 Illigera grandiflora 的具有胆碱酯酶抑制活性的新型二苯并吡咯啉生物碱
DOI：
10.1080/14786419.2019.1608542
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发表时间：
2019-05-03
影响因子：
2.2
通讯作者：
Ding, Zhongtao
中科院分区：
文献类型：
--
作者：
Li, Xuejiao;Dong, Jianwei;Ding, Zhongtao
从大花冬青（Illigera grandiflora W.）W. SM.等J. F.杰夫化合物1的结构经HRESIMS、1D/2D NMR和电子圆二色谱（ECD）确证。化合物1和2对乙酰胆碱酯酶有中等抑制活性，化合物3对丁酰胆碱酯酶有中等抑制活性。这是首次报道该属植物的化学成分。大花。
Abstract A new dibenzopyrrocoline alkaloid, (-)-grandifloramine (1), together with five known ones, actinodaphnine (2), N-methyllaurotetanine (3), boldine (4), lindcarpine (5), and (+)-norboldine (6), were isolated from Illigera grandiflora W. W. Sm. et J. F. Jeff. The structure of 1 was identified by HRESIMS, 1D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound 1 and 2 exhibited the moderate inhibitory activity against acetylcholinesterase and 3 showed moderate butyrylcholinesterase inhibitory activity. This is the first report of the chemical constituents of I. grandiflora.