CORTICOTROPIN RELEASING-FACTOR DECREASES POSTBURST HYPERPOLARIZATIONS AND EXCITES HIPPOCAMPAL-NEURONS
CORTICOTROPIN RELEASING-FACTOR DECREASES POSTBURST HYPERPOLARIZATIONS AND EXCITES HIPPOCAMPAL-NEURONS
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DOI：
10.1126/science.6603658
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
SIGGINS, GR
中科院分区：
文献类型：
--
作者：
ALDENHOFF, JB;GRUOL, DL;SIGGINS, GR
浓度为15-250 nmol/l的促肾上腺皮质激素释放因子增加了大鼠海马切片CA1和CA3锥体神经元爆发放电后的自发放电频率并降低了超极化的大小。浓度 > 250 nmol/l 也会使细胞去极化。促肾上腺皮质激素释放因子的这些兴奋作用可能涉及一种新的钙依赖性过程。
Corticotropin releasing factor in concentrations of 15-250 nmol/l increased the spontaneous discharge frequency and decreased the size of hyperpolarizations after burst discharges in CA1 and CA3 pyramidal neurons of rat hippocampal slices. Concentrations > 250 nmol/l also depolarized the cells. These excitatory actions of corticotropin releasing factor may involve a novel Ca-dependent process.