Histamine in the immune regulation of allergic inflammation
Histamine in the immune regulation of allergic inflammation
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DOI：
10.1067/mai.2003.1585
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发表时间：
2003-07-01
影响因子：
14.2
通讯作者：
Blaser, K
中科院分区：
文献类型：
--
作者：
Akdis, CA;Blaser, K
组胺是过敏、哮喘和过敏性休克机制中的第一个介质，因为已经发现它模拟这些疾病的几个特征。除了其在急性炎症和过敏反应中的良好表征的作用之外，最近证明组胺调节免疫反应中的几个基本事件。组胺影响免疫系统细胞的成熟并改变其活化、极化、趋化性和效应器功能。组胺还调节抗原特异性T（H）1和T（H）2细胞，以及相关的抗体同种型反应。组胺与4种不同的G蛋白偶联受体结合，这些受体通过不同的途径向细胞传递信号。这些受体在不同细胞和细胞亚群上的表达受到调节，显然，组胺对免疫调节的不同作用是由于4种组胺受体的差异表达及其不同的细胞内信号。这篇文章突出了组胺免疫生物学的新发现，并讨论了临床发现或疾病模型，表明组胺的免疫调节。
Histamine was the first mediator implicated in mechanisms of allergy, asthma, and anaphylactic shock because it has been discovered to mimic several features of these diseases. In addition to its well-characterized effects in the acute inflammatory and allergic responses, it was recently demonstrated that histamine regulates several essential events in the immune response. Histamine affects the maturation of immune system cells and alters their activation, polarization, chemotaxis, and effector functions. Histamine also regulates antigen-specific T(H)1 and T(H)2 cells, as well as related antibody isotype responses. Histamine binds to 4 different G protein-coupled receptors that transduce signals to cells through distinct pathways. The expression of these receptors on different cells and cell subsets is regulated, and apparently, the diverse effects of histamine on immune regulation are due to differential expression of 4 histamine receptors and their distinct intracellular signals. This article highlights novel discoveries in histamine immunobiology and discusses clinical findings or disease models that indicate immune regulation by histamine.