Splicing regulation in hematopoiesis.
Splicing regulation in hematopoiesis.
复制标题
DOI：
10.1097/moh.0000000000000661
复制
发表时间：
2021-07-01
影响因子：
3.2
通讯作者：
Abdel-Wahab O
中科院分区：
文献类型：
--
作者：
Chen S;Abdel-Wahab O
剪接突变是血液系统恶性肿瘤中最常见的遗传扰动之一，突出了剪接调控在造血发育中的重要影响。然而，与我们对恶性血液病中剪接因子突变的理解相比，对正常造血中剪接组分和选择性剪接的研究较少。在这里，我们概述了最新的研究结果剪接调节正常造血和讨论的重要问题，在该领域。最近的研究强调了剪接调控在造血中的关键作用，包括正常造血中剪接组分的表征，剪接的转录改变的调查，以及造血发育过程中阶段特异性选择性剪接事件的鉴定。这些有趣的发现提供了在共转录水平上对造血调控的见解。我们需要更多的高通量RNA测序和功能基因组筛选来提高我们对造血形成中关键的选择性剪接模式的认识。
Splicing mutations are among the most recurrent genetic perturbations in hematological malignancies, highlighting an important impact of splicing regulation in hematopoietic development. However, compared to our understanding of splicing factor mutations in hematological malignancies, studies of splicing components and alternative splicing in normal hematopoiesis have been less well investigated. Here, we outline the most recent findings on splicing regulation in normal hematopoiesis and discuss the important questions in the field. Recent studies have highlighted critical role of splicing regulation in hematopoiesis, including characterization of splicing components in normal hematopoiesis, investigation of transcriptional alterations on splicing, and identification of stage-specific alternative splicing events during hematopoietic development. These interesting findings provide insights on hematopoietic regulation at a co-transcriptional level. More high-throughput RNA sequencing and functional genomic screens are needed to advance our knowledge of critical alternative splicing patterns in shaping hematopoiesis.