Changes in the B-cell repertoire with age.
Changes in the B-cell repertoire with age.
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DOI：
10.1016/s0264-410x(99)00497-1
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发表时间：
2000-02
期刊：
影响因子：
5.5
通讯作者：
M. Weksler
中科院分区：
文献类型：
--
作者：
M. Weksler
Changes in the B-cell repertoire during aging include a shift in antibody specificities from foreign to autologous antigens associated with a decline in the activity of conventional B2 compared to B1 lymphocytes. The age-associated increase in B1 lymphocyte number and activity contribute to the increased serum concentration of autoantibodies and the B-cell clonal expansions that develop with age. Aging is also associated with a decreased diversity of the antibody response reflected in the preferential loss of IgG and high affinity antibodies following immunization with a foreign antigen. Many of these changes can be traced to an impaired capacity of T cells to support isotype switching and somatic mutation in the periphery and the generation of a diverse B-cell repertoire from bone marrow B-cell precursors.
