MECHANISM OF SPREADING CORTICAL DEPRESSION
MECHANISM OF SPREADING CORTICAL DEPRESSION
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DOI：
10.1152/jn.1956.19.2.154
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发表时间：
1956-01-01
影响因子：
2.5
通讯作者：
GRAFSTEIN, B
中科院分区：
文献类型：
--
作者：
GRAFSTEIN, B
在神经学上孤立的大脑皮层中，扩散性抑郁的发作引起皮层DC电位的缓慢负移，之前是短暂的强烈神经元活动的爆发。负电位偏移的幅度可以通过向皮层施加KCl或通过在抑郁症扩散的方向上将皮层极化为正到负来增加。相反方向的极化和局部强重复刺激降低了电位移动的幅度。阻断皮层血供和N2窒息均导致皮层负波的幅度和持续时间增加。这些事实进行了讨论的假设，抑郁症的传播依赖于释放的K+从皮层神经元。
In neurologically isolated cerebral cortex the onset of spreading depression causes a slow negative shift in cortical DC potential, preceded by a brief burst of intense neuronal activity. The amplitude of the negative potential shift may be increased by applying KC1 to the cortex or by polarizing the cortex positive-to-negative in the direction of spread of the depression. Polarization in the reverse direction and local strong repetitive stimulation decrease the amplitude of the potential shift. Clamping the cortical blood supply and asphyxiation by N2 both cause an increase in amplitude and duration of the cortical negativity. These facts are discussed in relation to the hypothesis that the spread of depression depends on the liberation of K+ from the cortical neurones.