Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.
Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.
复制标题
克隆的厌食阻滞在成熟T细胞的体内生长中，并且可以在没有抗原的情况下逆转。
DOI：
10.1084/jem.177.5.1517
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发表时间：
1993-05-01
影响因子：
15.3
通讯作者：
Von Boehmer, H
中科院分区：
文献类型：
--
作者：
Rocha, B;Tanchot, C;Von Boehmer, H
在各种模型中的实验表明，免疫耐受可由反应性淋巴细胞的物理消除(缺失)以及无能引起。我们以前已经报道，成熟的CD4-CD8+T细胞在面对其抗原时可以广泛增殖，但最终被消除或变得本质上无能，以至于剩余的细胞对任何T细胞受体配体的刺激都是不能的，即使在外源性白介素2存在的情况下也是如此。在这里，我们证明了在体内，在没有抗原的情况下无能是可以逆转的，这样细胞就能够在体内广泛地增殖，以应对相关抗原的新挑战。
Experiments in various models have indicated that immunological tolerance can result from the physical elimination (deletion) of reactive lymphocytes as well as from anergy. We have previously reported that mature CD4-CD8+ T cells when confronted with their antigen can proliferate extensively but are finally eliminated or become intrinsically anergic such that remaining cells are refractory to stimulation by any T cell receptor ligands, even in the presence of exogenous interleukin 2. Here we show that in vivo the anergy can be reversed in the absence of antigen, such that the cells are then able to proliferate extensively in vivo to a new challenge with the antigen in question.