Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s.
Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s.
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DOI：
10.1016/j.jaci.2021.03.015
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Kita H
中科院分区：
文献类型：
--
作者：
Bartemes KR;Kita H
自先天淋巴细胞（ILC）发现以来的12年中，我们对其免疫生物学的了解迅速扩大。组2 ILC（ILC2）对粘膜器官中的过敏原暴露和环境损伤快速响应，产生2型细胞因子。早期研究表明上皮细胞源性细胞因子激活ILC2，导致嗜酸性粒细胞增多、粘液分泌过多和粘膜组织重塑。我们现在知道ILC2也受其他细胞因子、类花生酸和神经肽的调节，并与免疫细胞和基质细胞相互作用。此外，ILC2表现出可塑性，通过调整其功能，这取决于他们的组织环境，并可能由几个异质亚群。临床研究表明ILC2与哮喘、变应性鼻炎、慢性鼻窦炎、食物过敏和嗜酸性食管炎有关。然而，许多仍然未知的免疫机制。ILC在维持或恢复组织健康和人类健康方面的有益功能也需要澄清。随着我们对ILC在体内平衡和疾病病理学中发挥的关键作用的理解的扩大，我们准备在过敏性疾病患者的诊断和治疗选择方面取得巨大进展。本文综述了近5年来ILC的免疫生物学研究进展及其在变态反应性疾病中的作用，讨论了目前存在的争议和不足，并提出了今后的研究方向。
In the twelve years since the discovery of innate lymphoid cells (ILCs), our knowledge of their immunobiology has expanded rapidly. Group 2 ILCs (ILC2s) respond rapidly to allergen exposure and environmental insults in mucosal organs, producing type 2 cytokines. Early studies showed epithelium-derived cytokines activate ILC2s, resulting in eosinophilia, mucus hypersecretion and remodeling of mucosal tissues. We now know that ILC2s are regulated by other cytokines, eicosanoids, and neuropeptides as well, and interact with both immune and stromal cells. Furthermore, ILC2s exhibit plasticity by adjusting their functions depending on their tissue environment and may consist of several heterogenous subpopulations. Clinical studies show that ILC2s are involved in asthma, allergic rhinitis, chronic rhinosinusitis, food allergy and eosinophilic esophagitis. However, much remains unknown about the immunological mechanisms involved. Beneficial functions of ILCs in maintenance or restoration of tissue well-being and human health also need to be clarified. As our understanding of the crucial functions ILCs play in both homeostasis and disease pathology expands, we are poised to make tremendous strides in diagnostic and therapeutic options for patients with allergic diseases. This review summarizes discoveries in immunobiology of ILCs and their roles in allergic diseases in the past 5 years, discusses controversies and gaps in our knowledge and suggests future research directions.
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影响因子：
24.8
作者：
Bankova LG;Dwyer DF;Yoshimoto E;Ualiyeva S;McGinty JW;Raff H;von Moltke J;Kanaoka Y;Frank Austen K;Barrett NA
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6.5
作者：
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