Roles of Immune Cells and Mechanisms of Immune Responses in Periodontitis.
Roles of Immune Cells and Mechanisms of Immune Responses in Periodontitis.
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DOI：
10.3290/j.cjdr.b2440547
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发表时间：
2022-01
期刊：
影响因子：
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通讯作者：
Xiao-wu Xu;Xia Liu;C. Shi;Hongchen Sun
中科院分区：
文献类型：
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作者：
Xiao-wu Xu;Xia Liu;C. Shi;Hongchen Sun
牙周炎是严重威胁人类口腔和全身健康的口腔疾病之一。它是由斑块微生物和宿主免疫系统之间的复杂相互作用引起的一种炎症性疾病。当病原体侵入牙周组织时，先天免疫反应被激活。过度的先天免疫反应会导致炎症和牙周组织的破坏，进而激活适应性免疫反应。尽管系统初始治疗和引导组织再生(GTR)能在一定程度上控制牙周炎症，促进牙周组织再生，但其效果仍然有限。如果有可能筛选潜在的治疗靶点并调控参与牙周病的关键分子，牙周治疗将得到显著改善；然而，有关牙周炎预防和治疗的相关研究仍然有限。因此，本文就病原菌在牙周组织中引起的先天免疫反应和获得性免疫反应所涉及的细胞和机制进行综述，以期对牙周炎的免疫调节有所帮助。
Periodontitis is one of the severe oral diseases that threatens both the oral and general health of humans. It is an inflammatory disease caused by the complex interaction between the plaque microorganisms and the host immune system. The innate immune response is activated when pathogens invade the periodontium. An excessive innate immune response leads to inflammation and the destruction of periodontal tissues, which then activates the adaptive immune response. Although systemic initial therapy and guided tissue regeneration (GTR) can control periodontal inflammation to a certain extent and promote periodontal tissue regeneration, their effects are still limited. Periodontal treatment will be significantly improved if it is possible to screen the potential therapeutic targets and regulate the key molecules involved in periodontal disease; however, relevant research on the prevention and treatment of periodontitis remains limited. Thus, with the aim of assisting the immunoregulation of periodontitis, this article summarises the cells and mechanisms involved in the innate immune response and adaptive immune response caused by pathogens in the periodontium.