Retrospective evaluation of echocardiographic variables for prediction of heart failure hospitalization in heart failure with preserved versus reduced ejection fraction: A single center experience.
Retrospective evaluation of echocardiographic variables for prediction of heart failure hospitalization in heart failure with preserved versus reduced ejection fraction: A single center experience.
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DOI：
10.1371/journal.pone.0244379
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Strom JB
中科院分区：
文献类型：
--
作者：
Hammond MM;Shen C;Li S;Kazi DS;Sabe MA;Garan AR;Markson LJ;Manning WJ;Klein AL;Nagueh SF;Strom JB
关于经胸超声心动图（TTE）变量在左心室（LV）收缩功能谱中预测心力衰竭（HF）再入院的差异能力的数据有限。我们将Beth Israel Deaconess Medical Center 15年的TTE报告数据（1/6/2003-5/3/2018）与完整的Medicare索赔相关联。在近期HF患者中，我们评估了基线TTE变量与HF再入院之间的关系，并按LVEF分层。在排除了具有不可解释的病理学的TTE后，纳入了5，900名个体（平均年龄：76.9岁; 49.1%为女性），其中2545名个体（41.6%）因HF入院。与人口统计学、合并症和超声心动图结构变量相比，舒张期变量增加了预测值（p < 0.001），但区分度不高（c-统计量= 0.63）。LV尺寸和离心性肥厚预测了收缩功能降低（HFrEF）但未保留（HFpEF）的HF患者的HF，而LV壁厚度、NT-proBNP、肺静脉D波和Ar波速度以及心房尺寸预测了HFpEF患者的HF，但未预测HFrEF患者的HF（所有相互作用p < 0.10）。HFpEF和HFrEF对HF再入院的预测无差异（p = 0.93）。在这项与医疗保险索赔相关的单中心超声心动图研究中，左心室尺寸和离心性肥厚预测了HFrEF患者的HF再入院，但不能预测HFpEF患者的HF再入院，左心室壁厚度预测了HFpEF患者的HF再入院，但不能预测HFrEF患者的HF再入院。无论LVEF如何，与超声心动图结构变量、人口统计学和合并症相比，舒张期变量增加了HF再入院的预测。未来的研究应考虑药物依从性、再入院史和功能状态在LVEF分类的HF再入院差异预测中的额外作用。
Limited data exist on the differential ability of variables on transthoracic echocardiogram (TTE) to predict heart failure (HF) readmission across the spectrum of left ventricular (LV) systolic function. We linked 15 years of TTE report data (1/6/2003-5/3/2018) at Beth Israel Deaconess Medical Center to complete Medicare claims. In those with recent HF, we evaluated the relationship between variables on baseline TTE and HF readmission, stratified by LVEF. After excluding TTEs with uninterpretable diastology, 5,900 individuals (mean age: 76.9 years; 49.1% female) were included, of which 2545 individuals (41.6%) were admitted for HF. Diastolic variables augmented prediction compared to demographics, comorbidities, and echocardiographic structural variables (p < 0.001), though discrimination was modest (c-statistic = 0.63). LV dimensions and eccentric hypertrophy predicted HF in HF with reduced (HFrEF) but not preserved (HFpEF) systolic function, whereas LV wall thickness, NT-proBNP, pulmonary vein D- and Ar-wave velocities, and atrial dimensions predicted HF in HFpEF but not HFrEF (all interaction p < 0.10). Prediction of HF readmission was not different in HFpEF and HFrEF (p = 0.93). In this single-center echocardiographic study linked to Medicare claims, left ventricular dimensions and eccentric hypertrophy predicted HF readmission in HFrEF but not HFpEF and left ventricular wall thickness predicted HF readmission in HFpEF but not HFrEF. Regardless of LVEF, diastolic variables augmented prediction of HF readmission compared to echocardiographic structural variables, demographics, and comorbidities alone. The additional role of medication adherence, readmission history, and functional status in differential prediction of HF readmission by LVEF category should be considered for future study.
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影响因子：
18.2
作者：
Nauta JF;Hummel YM;Tromp J;Ouwerkerk W;van der Meer P;Jin X;Lam CSP;Bax JJ;Metra M;Samani NJ;Ponikowski P;Dickstein K;Anker SD;Lang CC;Ng LL;Zannad F;Filippatos GS;van Veldhuisen DJ;van Melle JP;Voors AA
通讯作者：
Voors AA
DOI：
10.1161/circoutcomes.118.005048
发表时间：
2018-10
期刊：
Circulation. Cardiovascular quality and outcomes
影响因子：
--
作者：
Kundi H;Valsdottir LR;Popma JJ;Cohen DJ;Strom JB;Pinto DS;Shen C;Yeh RW
通讯作者：
Yeh RW
影响因子：
7.5
作者：
Nagueh, Sherif F.;Bhatt, Rajat;Estep, Jerry D.
通讯作者：
Estep, Jerry D.
影响因子：
2.8
作者：
Kundi, Harun;Popma, Jeffrey J.;Yeh, Robert W.
通讯作者：
Yeh, Robert W.
影响因子：
24
作者：
Kundi, Harun;Popma, Jeffrey J.;Yeh, Robert W.
通讯作者：
Yeh, Robert W.