Dietary arginine fails to protect against cerebrovascular damage in stroke-prone hypertensive rats.
Dietary arginine fails to protect against cerebrovascular damage in stroke-prone hypertensive rats.
复制标题
膳食精氨酸不能保护易发生中风的高血压大鼠免受脑血管损伤。
DOI：
10.1016/0006-8993(91)90482-b
复制
发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Levine,S
中科院分区：
文献类型：
--
作者：
StierJr,CT;Sim,GJ;Levine,S
Stroke-prne spontaneously hypertensive rats (SHRSP) develop severe hypertension and cerebrovascular lesions. We investigated the influence of dietary supplementation withl-arginine, an amino acid precursor of endothelium-derived nitric oxide, on blood pressure and stroke in these rats.l-Arginine, administered in the saline drinking solution at 2 or 6 g/l starting at 8.7 weeks of age, was without effect on blood pressure, cerebrovascular lesions, or longevity despite continuous treatment through 14 weeks of age. These findings do not support a beneficial influence of dietary arginine in the cerebrovascular pathology of SHRSP.
