Calcium signalling initiated by CR1 (CD35) crosslinking is mediated by phagocyte Fc gamma receptors in cis.
Calcium signalling initiated by CR1 (CD35) crosslinking is mediated by phagocyte Fc gamma receptors in cis.
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CR1 (CD35) 交联引发的钙信号传导由顺式吞噬细胞 Fc gamma 受体介导。
DOI：
10.1006/bbrc.1995.1601
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发表时间：
1995
影响因子：
3.1
通讯作者：
Zimmerli,S
中科院分区：
文献类型：
--
作者：
Ernst,JD;Rosales,JL;Zimmerli,S
我们研究了 1 型补体受体 (CR1；CD35) 在吞噬细胞（特别是人中性粒细胞）中产生细胞内信号的作用。我们发现单独的 CR1 交联不能导致细胞内离子钙 [Ca2+]i 的增加。然而，与 CR1 结合的 IgG 能够与 Fcγ 受体相互作用，刺激 [Ca2+]i 增加。通过检查混合细胞群中产生的信号，我们确定只有当 CR1 和 Fcγ 受体作用于同一细胞时才会观察到钙的增加。补体受体和免疫球蛋白 G 受体之间的功能性相互作用可能会促进结合有限数量的补体和 IgG 的病原菌和真菌的清除。
We have examined the role of complement receptor type 1 (CR1; CD35) in generating intracellular signals in phagocytic cells, particularly human neutrophils. We find that crosslinking of CR1 alone fails to result in an increase in intracellular ionized calcium [Ca2+]i. However, IgG bound to CR1 is able to interact with Fcγ receptors to stimulate increases in [Ca2+]i. By examining signals generated in mixed populations of cells, we determined that calcium increases are observed only when CR1 and Fcγ receptors are engaged on the same cell. Functional interactions between complement receptors and receptors for immunoglobulin G may promote clearance of pathogenic bacteria and fungi that bind limited quantities of complement and IgG.