Detecting single porphyrin molecules in a conically shaped synthetic nanopore
Detecting single porphyrin molecules in a conically shaped synthetic nanopore
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DOI：
10.1021/nl050925i
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发表时间：
2005-09-01
期刊：
影响因子：
10.8
通讯作者：
Martin, CR
中科院分区：
文献类型：
--
作者：
Heins, EA;Siwy, ZS;Martin, CR
我们在这里报告了分子(相对于粒子或大分子)分析物的非生物阻性脉冲传感的第一个例子。这是通过使用径迹蚀刻方法制备的圆锥形纳米孔作为传感元件来实现的。检测分子分析物是可能的，因为锥形纳米孔的小直径开口(类似于4.5 nm)与分析物分子的直径(类似于2 nm)相当。
We report here the first example of abiotic resistive-pulse sensing of a molecular (as opposed to a particle or macromolecular) analyte. This was accomplished by using a conically shaped nanopore prepared by the track-etch method as the sensing element. It is possible to sense the molecular analyte because the small diameter opening of the conical nanopore (similar to 4.5 nm) is comparable to the diameter of the analyte molecule (similar to 2 nm).