The cytokine and chemokine network in psoriasis
The cytokine and chemokine network in psoriasis
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DOI：
10.1016/j.clindermatol.2007.08.011
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发表时间：
2007-11-01
影响因子：
2.7
通讯作者：
Qin, Jian-Zhong
中科院分区：
文献类型：
--
作者：
Nickoloff, Brian J.;Xin, Hong;Qin, Jian-Zhong
银屑病斑块的形成和维持需要多细胞共谋，通过该共谋，银屑病前皮肤被多种免疫细胞浸润，引发表皮角质形成细胞和内皮细胞行为的变化。这些复杂的细胞事件需要空间和时间的协调才能实现成熟的斑块。决定斑块内细胞行为和运动的关键分子协调员包括细胞因子和趋化因子。这些炎症介质在银屑病的病理生理学中发挥着重要作用。本章的目的是对银屑病皮肤病变中的细胞因子和趋化因子网络进行最新综述。 (c) 2007 Elsevier Inc. 保留所有权利。
Creation and maintenance of psoriatic plaques require a multicellular conspiracy by which prepsoriatic skin becomes infiltrated by a variety of immunocytes triggering changes in the behavior of epidermal keratinocytes and endothelial cells. These complex cellular events require coordination in space and time to achieve the mature plaque. Key molecular coordinators dictating behavior and movement of cells within plaques include cytokines as well as chemokines. These mediators of inflammation play fundamentally important roles in the pathophysiology of psoriasis. The purpose of this chapter is to provide an updated review of cytokine and chemokine networks in psoriatic skin lesions. (c) 2007 Elsevier Inc. All rights reserved.