IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY
IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY
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DOI：
10.1038/258577a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
MORRIS, HR
中科院分区：
文献类型：
--
作者：
HUGHES, J;SMITH, TW;MORRIS, HR
脑啡肽是阿片受体的天然配体，由五肽H-Tyr-Gly-Gly-Phe-Met-OH和H-Tyr-Gly-Gly-Phe-Leu-OH组成。证据是基于用danyl - edman程序和质谱法测定天然脑啡肽的氨基酸序列，然后合成和比较天然肽和合成肽。
Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H–Tyr–Gly–Gly–Phe–Met–OH and H–Tyr–Gly–Gly–Phe–Leu–OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl–Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.