Interspecies Comparison of Chemical Composition and Anxiolytic-like Effects of Lavender Oils upon Inhalation
Interspecies Comparison of Chemical Composition and Anxiolytic-like Effects of Lavender Oils upon Inhalation
复制标题
薰衣草油化学成分和吸入后的抗焦虑作用的种间比较
DOI：
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发表时间：
2011
影响因子：
1.8
通讯作者：
K. Koike
中科院分区：
文献类型：
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作者：
Mizuho Takahashi;T. Satou;Mai Ohashi;S. Hayashi;K. Sadamoto;K. Koike
几十年来，传统上一直使用精油来缓解各种精神问题的症状。就抗焦虑类特性而言，薰衣草油可能是最常用和研究最多的精油。尽管从不同来源提取的精油成分存在差异，但迄今为止很少有研究调查这些差异如何影响抗焦虑样活性的表达。本文通过比较6种不同薰衣草精油，探讨了其主要成分在吸入后抗焦虑样作用表达中的种间差异和贡献。结果显示，在测试油的定性和定量的差异，这导致他们的抗焦虑活性显著差异。我们的研究结果还表明，乙酸芳樟醇（LA）与芳樟醇（LO）协同作用，LA和LO的存在对于整个油作为吸入抗焦虑剂的作用是必不可少的。
Essential oils have traditionally been used for decades to alleviate the symptoms of various mental problems. In terms of anxiolytic-like properties, lavender oil is probably the most commonly used and best-studied essential oil. Although there is compositional variance among the oils extracted from different origins, there have been few studies performed to date to investigate how these differences affect the expression of anxiolytic-like activity. This paper discusses the interspecies differences and contributions of the main constituents in the expression of anxiolytic-like effects upon inhalation, as assessed in mice by the elevated-plus maze test, by comparing the essential oils from six different species of Lavandula. The results showed qualitative and quantitative variations in the tested oils, which results in significant differences in their anxiolytic-like activities. Our findings also suggest that linalyl acetate (LA) works synergistically with linalool (LO) and that the presence of both LA and LO is essential for the whole oil to work as an inhaled anti-anxiety agent.
影响因子：
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作者：
Kessler, RC;Chiu, WT;Walters, EE
通讯作者：
Walters, EE