Serum angiopoietin-2 concentrations of post-PCI are correlated with the parameters of renal function in patients with coronary artery disease
Serum angiopoietin-2 concentrations of post-PCI are correlated with the parameters of renal function in patients with coronary artery disease
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冠心病患者PCI术后血清血管生成素2浓度与肾功能参数相关
DOI：
10.1097/md.0000000000013960
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发表时间：
2019-01-01
期刊：
影响因子：
1.6
通讯作者：
Gui, Chun
中科院分区：
文献类型：
--
作者：
Jian, Wen;Li, Lang;Gui, Chun
摘要冠心病(CAD)患者常合并慢性肾病(CKD)。经皮冠状动脉介入治疗(PCI)后使用造影剂可能导致肾功能恶化。血管生成素-2(Ang-2)在血管生成部位高表达，在冠心病和慢性肾脏病中发挥重要作用。本研究旨在探讨经皮冠状动脉介入治疗术后血清Ang-2浓度与肾功能的关系。这项研究纳入了57名接受经皮冠状动脉介入治疗的冠心病患者。于入院后第1天早晨及术后24~48 h内采血检测血管紧张素2。分别于入院第1天及术后72 h内检测肾功能指标(血肌酐、胱抑素C、表皮生长因子受体)。总体而言，术后血清Ang-2水平显著低于术前[中位数，1733(IQR1100-2568)vs2523(IQR1702-3640)pg/mL；P <； .001]。而慢性肾功能不全患者(EGFR <； 60min/ /1.73pg/m in~2)，术后血清Ang-2水平与术前无显著差异[中位数，2851(IQR1720~4286)vs.2492(IQR1434~4994)pg/mL；P = .925]。此外，冠状动脉介入治疗后血清Ang-2水平与术后肾功能参数显著相关，但与介入治疗前无关。冠心病患者经皮冠状动脉介入治疗后血清Ang-2浓度与肾功能密切相关。它有可能成为造影剂肾病的早期生物标志物。
Abstract Patients with coronary artery disease (CAD) frequently have comorbidity of chronic kidney disease (CKD). Their renal function may deteriorate because of the use of contrast agent after percutaneous coronary intervention (PCI). Angiopoietin-2 (Ang-2), which is highly expressed in the site of angiogenesis, plays an important role in both CAD and CKD. This study aimed to investigate the relation of serum Ang-2 concentrations with the renal function after PCI. This study enrolled 57 patients with CAD undergoing PCI. Blood samples for Ang-2 were collected in the first morning after admission and within 24 to 48 h after PCI. The parameters of renal function (serum creatinine, cystatin C and eGFR) were tested on the first day after admission and within 72 h after PCI. Overall, serum Ang-2 levels of post-PCI were significantly lower than those of pre-PCI [median, 1733 (IQR, 1100–2568) vs median, 2523 (IQR, 1702–3640) pg/mL; P < .001]. However, in patients with CKD (eGFR < 60 mL/min/1.73 m2), there was no significant difference between serum Ang-2 levels of post-PCI and those of pre-PCI [median, 2851 (IQR, 1720–4286) vs. median, 2492 (IQR, 1434–4994) pg/mL; P = .925]. In addition, serum Ang-2 levels of post-PCI, but not pre-PCI, were significantly correlated with the post-PCI parameters of renal function. Serum Ang-2 concentrations of post-PCI are closely related to renal function in patients with CAD. It may have potential to be the early biomarker of contrast-induced nephropathy in the future.