FACTORS AFFECTING INTELLECTUAL OUTCOME IN PEDIATRIC BRAIN-TUMOR PATIENTS
FACTORS AFFECTING INTELLECTUAL OUTCOME IN PEDIATRIC BRAIN-TUMOR PATIENTS
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DOI：
10.1227/00006123-198711000-00006
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发表时间：
1987-11-01
期刊：
影响因子：
4.8
通讯作者：
STOWE, S
中科院分区：
文献类型：
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作者：
ELLENBERG, L;MCCOMB, JG;STOWE, S
一项前瞻性研究利用重复智力测试对连续入住美国加利福尼亚州洛杉矶儿童医院的 73 名患有脑肿瘤的儿童进行了 3 年的研究，以确定肿瘤位置、手术切除范围、脑积水、儿童年龄、放射治疗和化疗对认知结果的影响。对 43 名患者进行了至少两次连续的智力评估随访，并为本研究提供了数据。 患有半球肿瘤的儿童有最普遍的认知障碍。肿瘤切除的程度、脑积水的充分治疗和化疗对智力结果没有影响。孩子的年龄影响结果主要是因为它与辐射有关。全脑放射治疗与认知能力下降有关。对于 7 岁以下的儿童尤其如此，他们在接受全脑放射治疗后经历了非常显着的功能丧失。
A prospective study utilizing repeated intellectual testing was undertaken in 73 children with brain tumors consecutively admitted to Childrens Hospital of Los Angeles [California, USA] over a 3-year period to determine the effect of tumor location, extent of surgical resection, hydrocephalus, age of the child, radiation therapy, and chemotherapy on cognitive outcome. Forty-three patients were followed for at least two sequential intellectual assessments and provide the data for this study. Children with hemispheric tumors had the most general cognitive impairment. The degree of tumor resection, adequately treated hydrocephalus, and chemotherapy had no bearing on intellectual outcome. Age of the child affected outcome mainly as it related to radiation. Whole brain radiation therapy was associated with cognitive decline. This was especially true in children below 7 years of age, who experienced a very significant loss of function after whole brain radiation therapy.