Transmission-Dependent Tolerance to Multiclonal Plasmodium falciparum Infection
Transmission-Dependent Tolerance to Multiclonal Plasmodium falciparum Infection
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DOI：
10.1086/605652
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发表时间：
2009-10-01
影响因子：
6.4
通讯作者：
Marsh, Kevin
中科院分区：
文献类型：
--
作者：
Farnert, Anna;Williams, Thomas N.;Marsh, Kevin
在肯尼亚沿海不同传播水平地区的儿童中调查了无症状恶性疟原虫感染的并发克隆数是否反映了宿主保护的程度。基于msp2的多态性确定并行克隆的数目，msp2编码疫苗候选抗原裂殖子表面蛋白2。在低传播地区，大多数儿童患有单克隆感染，多样性并不能预测临床疟疾的风险。在中度传播的地区，与1个克隆相比，2个克隆的无症状感染与随后疟疾的风险增加有关。在坦桑尼亚一个高传播地区的比较评估中，多克隆感染降低了风险。克隆数量与疟疾发病率之间的不同非线性关系表明，对多克隆感染的耐受水平是传播依赖性的，这是由于累积暴露于抗原多样性的恶性疟原虫感染。
Whether the number of concurrent clones in asymptomatic Plasmodium falciparum infections reflects the degree of host protection was investigated in children living in areas with different levels of transmission on the coast of Kenya. The number of concurrent clones was determined on the basis of polymorphism in msp2, which encodes the vaccine candidate antigen merozoite surface protein 2. In a low-transmission area, most children had monoclonal infections, and diversity did not predict a risk of clinical malaria. In an area of moderate transmission, asymptomatic infections with 2 clones were, compared with 1 clone, associated with an increased risk of subsequent malaria. In a comparative assessment in a high-transmission area in Tanzania, multiclonal infections conferred a reduced risk. The different nonlinear associations between the number of clones and malaria morbidity suggest that levels of tolerance to multiclonal infections are transmission dependent as a result of cumulative exposure to antigenically diverse P. falciparum infections.