THE COMPLEXITIES OF EUKARYOTIC TRANSCRIPTION INITIATION - REGULATION OF PREINITIATION COMPLEX ASSEMBLY
THE COMPLEXITIES OF EUKARYOTIC TRANSCRIPTION INITIATION - REGULATION OF PREINITIATION COMPLEX ASSEMBLY
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DOI：
10.1016/0968-0004(91)90164-q
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发表时间：
1991-11-01
影响因子：
13.8
通讯作者：
ROEDER, RG
中科院分区：
文献类型：
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作者：
ROEDER, RG
RNA聚合酶II和一般起始因子组装成预起始复合物的各个步骤作为激活剂的控制点，其功能需要额外的辅因子。激活剂诱导的全范围似乎涉及逆转负约束和净正效应启动子与一般因子的相互作用。
Individual steps in the assembly of RNA polymerase II and general initiation factors into a preinitiation complex serve as points of control for activators, whose functions require additional cofactors. The full range of induction by activators appears to involve both the reversal of negative constraints and net positive effects on promoter interactions with general factors.