Dexamethasone transiently attenuates up-regulation of endostatin/collagen XVIII following traumatic brain injury
Dexamethasone transiently attenuates up-regulation of endostatin/collagen XVIII following traumatic brain injury
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DOI：
10.1016/j.neuroscience.2007.04.052
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发表时间：
2007-07-13
期刊：
影响因子：
3.3
通讯作者：
Schluesener, H. J.
中科院分区：
文献类型：
--
作者：
Zhang, Z.-Y.;Zhang, Z.;Schluesener, H. J.
内皮抑素/XVIII 胶原蛋白是体外内皮细胞增殖和迁移的特异性抑制剂。它还在体内和体外被证明具有抗血管生成活性和肿瘤生长抑制活性。在这里，我们研究了大鼠创伤性脑损伤 (TBI) 模型中内皮抑素/XVIII 胶原蛋白的表达，重点关注早期阶段。 TBI 中内皮抑素/XVIII 胶原蛋白早在 TBI 后 24 小时就开始显着上调。双重染色实验表明，我们的 TBI 大鼠模型中内皮抑素/胶原蛋白 XVIII+ 细胞的主要来源是重新激活的小胶质细胞/巨噬细胞亚群。我们的数据进一步表明，地塞米松在 TBI 后第 1 天和第 2 天减弱了内皮抑素/XVIII 胶原蛋白表达的上调，但在第 4 天没有减弱，这表明地塞米松可能对 TBI 后的血管生成具有早期和短暂的影响。 (c) 2007 年国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
Endostatin/collagen XVIII is a specific inhibitor of endothelial proliferation and migration in vitro. It has also been shown to have anti-angiogenic activity and tumor growth inhibitory activity in vivo and in vitro. Here we studied expression of endostatin/collagen XVIII in a rat traumatic brain injury (TBI) model, focusing on the early phase. A significant up-regulation of endostatin/collagen XVIII in TBI began as early as 24 h post-TBI. Double-staining experiment revealed that the major resource of endostatin/collagen XVIII+ cells in our TBI rat model was a subpopulation of reactivated microglia/macrophages. Our data further showed that dexamethasone attenuated up-regulation of endostatin/collagen XVIII expression at days 1 and 2, but not at day 4, post-TBI, indicating that dexamethasone might possess an early and transient influence to the angiogenesis following TBI. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.