Synthesis, properties and applications of biodegradable polymers derived from diols and dicarboxylic acids: from polyesters to poly(ester amide)s.

Synthesis, properties and applications of biodegradable polymers derived from diols and dicarboxylic acids: from polyesters to poly(ester amide)s.
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DOI:
10.3390/ijms15057064
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发表时间:
2014-04-25
影响因子:
5.6
通讯作者:
Puiggalí J
Puiggalí J
中科院分区:
生物学2区
文献类型:
--
作者:
Díaz A;Katsarava R;Puiggalí J

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聚(亚烷基二甲酸乙二醇酯)S是一类生物可降解聚合物,在商品和特种应用方面越来越受到人们的关注。这些聚合物大多可以由生物二元醇和二元酸(如1,4-丁二醇、丁二酸和碳水化合物)制备。本文综述了一系列聚合物的合成、生物降解及其应用的现状报告,这些聚合物包括从弹性到刚性的材料,适用于水凝胶、软组织工程、药物输送系统和液晶等应用。最后,考虑了芳香族单元和α-氨基酸的结合,因为分子链的刚性和分子间的相互作用可以显著改变。事实上,由天然氨基酸衍生的聚酯酰胺S作为生物可降解材料在生物医学中的应用也得到了广泛的讨论。
Poly(alkylene dicarboxylate)s constitute a family of biodegradable polymers with increasing interest for both commodity and speciality applications. Most of these polymers can be prepared from biobased diols and dicarboxylic acids such as 1,4-butanediol, succinic acid and carbohydrates. This review provides a current status report concerning synthesis, biodegradation and applications of a series of polymers that cover a wide range of properties, namely, materials from elastomeric to rigid characteristics that are suitable for applications such as hydrogels, soft tissue engineering, drug delivery systems and liquid crystals. Finally, the incorporation of aromatic units and α-amino acids is considered since stiffness of molecular chains and intermolecular interactions can be drastically changed. In fact, poly(ester amide)s derived from naturally occurring amino acids offer great possibilities as biodegradable materials for biomedical applications which are also extensively discussed.
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