Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk?
Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk?
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DOI：
10.1016/j.jpsychires.2009.05.006
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发表时间：
2009-12-01
影响因子：
4.8
通讯作者：
Spiegel, David
中科院分区：
文献类型：
--
作者：
Taylor, C. Barr;Conrad, Ansgar;Spiegel, David
为了确定情绪改善是否能改善心血管疾病风险升高的抑郁症患者的自主神经调节障碍、HPA功能障碍、典型危险因素和C反应蛋白，48名心血管风险因素升高的抑郁症参与者被随机分为认知行为干预(CBT)和排队对照(WLC)两组。还招募了20名非抑郁年龄和风险匹配的对照组。在治疗前和治疗6个月后评估传统的危险因素(如血脂、血压)和C反应蛋白。受试者还接受了心理生理应激测试，同时测量了心血管生理学。在白天和心理应激测试期间测量唾液皮质醇。在治疗后，CBT受试者的抑郁程度明显低于WLC受试者。除甘油三酯水平和心率显著低于对照组外，在任何传统风险因素或C-反应蛋白、皮质醇测量或心血管生理学方面的变化分数都没有显著差异。正常对照组在同一时间内测量的变量没有变化。情绪的显著改善可能对大多数传统或非典型风险因素--皮质醇或心脏生理学--几乎没有影响。(C)2009爱思唯尔有限公司。保留所有权利。
To determine if improvement in mood would ameliorate autonomic dysregulation, HPA dysfunction, typical risk factors and C-reactive protein in depressed patients with elevated cardiovascular disease risk (CVD), 48 depressed participants with elevated cardiovascular risk factors were randomized to a cognitive behavioral intervention (CBT) or a waiting list control (WLC) condition. Twenty non-depressed age and risk-matched controls were also recruited. Traditional risk factors (e.g., lipids, blood pressure) and C-reactive protein were assessed pre- and post-treatment six months later. Subjects also underwent a psychophysiological stress test while cardiovascular physiology was measured. Salivary cortisol was measured during the day and during the psychological stress test. At post-treatment, the CBT subjects were significantly less depressed than WLC subjects. There was no significant difference in change scores on any of the traditional risk factors or C-reactive protein, cortisol measures, or cardiovascular physiology, except for triglyceride levels and heart rate, which were significantly lower in treatment compared to control subjects. The normal controls exhibited no change in the variables measured during the same time. A significant improvement in mood may have little impact on most traditional or atypical risk factors, cortisol or cardiophysiology. (C) 2009 Elsevier Ltd. All rights reserved.