Proliferative radiation retinopathy
Proliferative radiation retinopathy
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DOI：
10.1001/archopht.1996.01100140299007
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发表时间：
1996-09-01
影响因子：
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通讯作者：
Barlow, WE
中科院分区：
文献类型：
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作者：
Kinyoun, JL;Lawrence, BS;Barlow, WE
目的：比较增殖性放射性视网膜病变（PRR）与非增殖性放射性视网膜病变（NPRR），并评估全视网膜光凝治疗PRR.Methods的结果：我们回顾了10例（14只眼）PRR患者的病历，眼底照片和荧光素血管造影，这是诊断在三级转诊中心在20年的时间。收集的数据包括以下内容：放射治疗的适应症、使用的放射治疗技术、放射剂量和分数、视力、光凝治疗的适应症、使用的光凝技术和治疗反应。与数据进行了比较，从17例（27眼）NPRR，没有进展到PRR在本study.Results的过程中：PRR的14只眼睛的初始视力范围从20/20手的运动，这些眼睛的中位视力为20/90。27只NPRR患眼的初始视力范围为20/15至20/400;这些患眼的中位视力为20/25。PRR的5只眼（36%）和NPRR的4只眼（15%）（P= 0.35）的视力为20/200或更差。PRR组平均随访75个月，NPRR组平均随访51个月，中位视力分别为20/400和20/50; PRR组14只眼中有12只（86%）视力低于20/200，NPRR组27只眼中有7只（26%）视力低于20/200（P < 0.01）。
Objectives: To compare proliferative radiation retinopathy (PRR) with nonproliferative radiation retinopathy (NPRR) and to assess the outcome of panretinal photocoagulation treatment for PRR.Methods: We reviewed the medical records, fundus photographs, and fluorescein angiograms of 10 patients (14 eyes) with PRR, which was diagnosed in a tertiary referral center during a 20-year period. The collected data included the following: the indications for radiation treatment, radiotherapy technique used, dose and fractions of radiation, visual acuity, indications for photocoagulation treatment, photocoagulation technique used, and response to treatment. Comparisons were made with data from 17 patients (27 eyes) with NPRR, which had not progressed to PRR during the course of this study.Results: The initial visual acuity of the 14 eyes with PRR ranged from 20/20 to hand motion; these eyes had a median visual acuity of 20/90. The initial visual acuity of the 27 eyes with NPRR ranged from 20/15 to 20/400; these eyes had a median visual acuity of 20/25. Five (36%) of the eyes with PRR and 4 (15%) of the eyes with NPRR (P=.35) had a visual acuity of 20/200 or worse. After a mean follow-up time of 75 months for the eyes with PRR and 51 months for the eyes with NPRR, the median visual acuities were 20/400 and 20/50, respectively; 12 (86%) of the 14 eyes with PRR had a visual acuity of 20/200 or worse vs 7 (26%) of the 27 eyes with NPRR (P