Temporal and spatial adaptation to food restriction in mice under naturalistic conditions
Temporal and spatial adaptation to food restriction in mice under naturalistic conditions
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DOI：
10.1016/s0166-4328(00)00234-5
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发表时间：
2000-10-01
影响因子：
2.7
通讯作者：
Lipp, HP
中科院分区：
文献类型：
--
作者：
Dell'Omo, G;Ricceri, L;Lipp, HP
自由生活的雌性实验室小鼠适应了在提供自然环境的大围栏中的户外生活，测试了它们改变觅食习惯以控制食物供应的能力。一个自动喂食箱将每天种子数量的一小部分送到每只小鼠手中。八个这样的盒子被放进一个户外围栏里。每天，老鼠必须访问所有的盒子来收集每天的食物，并且只有在第一次访问每个盒子时才能获得奖励。植入的微芯片可以单独识别老鼠。在整个16天期间，喂食活动集中在每日会话开始前后的一段间隔时间。在同一时期，小鼠每天拜访的不同喂食者的数量增加，而不考虑探索活动的变化。该实验装置允许检测对食物限制的时间和空间适应，以及由于领土和社会因素造成的行为差异。这些数据允许设计新的测试，评估正常和转基因小鼠的行为变化、记忆和学习，无论是在实验室还是在自然环境中。(C)2000 Elsevier Science B.V.保留所有权利。
Free-living female laboratory mice, adapted to outdoor life in large pens providing a naturalistic environment, were tested for their ability to modify their foraging habits to controlled food supply. An automatic feeder box delivered a small portion of the daily quantity of seeds to each individual mouse. Eight such boxes were placed into an outdoor pen. Each day, mice had to visit all boxes to gather the daily amount of food and were rewarded only at the first visit to each box. Mice were individually recognised by an implanted microchip. Throughout a 16-day period, feeding activity concentrated in an interval time around the beginning of the daily session. During the same period, the number of different feeders visited every day by mice increased irrespective of variation in exploratory activity. The experimental set-up allowed detecting temporal and spatial adaptations to the food restriction, as well as behavioural differences due to territorial and social factors. These data permit the design of novel tests assessing behavioural changes, memory and learning in normal and genetically modified mice, both in the laboratory and in naturalistic settings. (C) 2000 Elsevier Science B.V. All rights reserved.