Efficient short step synthesis of Corey's tamiflu intermediate
Efficient short step synthesis of Corey's tamiflu intermediate
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DOI：
10.1021/ol7029646
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发表时间：
2008-03-06
期刊：
影响因子：
5.2
通讯作者：
Iwagawa, Tetsuo
中科院分区：
文献类型：
--
作者：
Kipassa, Nsiama Tienabe;Okamura, Hiroaki;Iwagawa, Tetsuo
Corey's tamiflu intermediate was synthesized from a bicyclolactam adduct obtained by base-catalyzed Diels-Alder reaction of N-nosyl-3-hydroxy-2-pyridone with ethyl acrylate. A compound that has the same array of functional groups with the Corey's intermediate was obtained in four steps from the DA adduct in 47% overall yield. The intermediate itself was also prepared efficiently by simply changing the protective group.
