PosterDetermination of heavy metals in proprietary Chinese medicines by inductively coupled plasma–mass spectrometry
PosterDetermination of heavy metals in proprietary Chinese medicines by inductively coupled plasma–mass spectrometry
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DOI：
10.1016/j.cca.2010.02.046
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发表时间：
2010-06
影响因子：
5
通讯作者：
F. Sa;W. Vong;T. Chan;C. Lam
中科院分区：
文献类型：
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作者：
F. Sa;W. Vong;T. Chan;C. Lam
方法按照《中华人民共和国药典》2005年版的方法，样品经浓硝酸微波消解后，用电感耦合等离子体质谱法进行分析结果三个样品被283-795 μg/天的Pb污染，而一个样品被2219 μg/天的As污染，均分别超过179 μg/天和1500 μg/天的允许限值（澳门卫生局）。另外4个样品被发现同时受到砷和汞的污染，但污染物被声称是硫化砷和硫化汞，它们在中国传统文化中被用作矿物药物已有几个世纪的历史。铜在1个样品中检测到210毫克/公斤，但这种金属的安全限度仍未确定在澳门.ConclusionsOur调查结果是绝不惊人的中成药在澳门市场的质量。然而，他们应该提醒消费者有毒重金属污染的潜在健康危害。建议药品生产企业在药品标签和说明书中说明服用汞、砷硫化物等矿物药的潜在危害。澳门卫生局应制定及执行中成药中铜的容许限量。
MethodsFollowing the method of the Pharmacopoeia of People's Republic of China 2005, samples were microwave digested with concentrated nitric acid before analysis by ICP–MS (Model 7500a, Agilent).ResultsThree samples were contaminated with Pb at 283–795 μg/day, while 1 sample was contaminated with As at 2219 μg/day, both exceeding the allowable limits of 179 μg/day and 1500 μg/day respectively (Macau Health Bureau). Another 4 samples were found to be contaminated both with As and Hg but the contaminants were claimed to be arsenic sulfide and mercury sulfide that had been used as mineral drugs in traditional Chinese culture for centuries. Cu was detected in 1 sample at 210 mg/kg but the safety limit of this metal remained undetermined in Macau.ConclusionsOur findings were by no means alarming with regard to the quality of proprietary Chinese medicines in the Macau market. However, they should alert consumers of the potential health hazards of contamination by toxic heavy metals. It is suggested that pharmaceutical manufacturers should state in the labeling and product inserts the potential hazard of taking mineral drugs like mercury and arsenic sulfides. The Macau Health Bureau should establish and enforce an allowable limit for Cu in proprietary Chinese medicines.