RIGulation of STING expression: at the crossroads of viral RNA and DNA sensing pathways.
RIGulation of STING expression: at the crossroads of viral RNA and DNA sensing pathways.
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DOI：
10.14800/ics.1491
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发表时间：
2017-01-01
影响因子：
--
通讯作者：
Olagnier D
中科院分区：
文献类型：
--
作者：
Liu Y;Lin R;Olagnier D
病原体的先天免疫感应对于宿主发起防御反应非常重要。近年来，STING 已成为对源自病原体的胞质 DNA 和 RNA 的免疫反应中的关键信号传导适配器。刘等人。 (2016) 证明 RIG-I 依赖性 RNA 传感信号通过 TNF-α 和 IFN-α 协同作用诱导 STING 表达。 STING 的上调对于 HSV 的 5'pppRNA 限制至关重要，HSV 是一种在体外和体内感染人类并引起疱疹的 DNA 病毒。这项研究通过 STING 的控制为 DNA 和 RNA 病原体传感系统之间的交互提供了新的见解。
The innate immune sensing of pathogens is important for host to mount defensive responses. STING has emerged in recent years as a critical signaling adaptor in the immune response to cytosolic DNA and RNA derived from pathogens. Liu et al. (2016) demonstrate that the RIG-I-dependent RNA sensing signaling induces STING expression via a TNF-α and IFN-α synergy. The up-regulation of STING is vital for 5′pppRNA restriction of HSV, a DNA virus that infects humans and causes herpes, in vitro and in vivo. This study provides new insights into the cross talk between DNA and RNA pathogen-sensing systems via the control of STING.