The role of CRH receptors and their agonists in myometrial contractility and quiescence during pregnancy and labour
The role of CRH receptors and their agonists in myometrial contractility and quiescence during pregnancy and labour
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DOI：
10.2741/2082
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发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Grammatopoulos, Dimitris K.
中科院分区：
文献类型：
--
作者：
Grammatopoulos, Dimitris K.
人类劳动的机制仍然是一个科学之谜。促肾上腺皮质激素释放激素（CRH）是一种下丘脑肽，控制身体对压力的反应，也是在怀孕期间由胎盘和子宫内组织产生的，可能与分娩的开始有关。CRH是哺乳动物肽家族的一部分，该家族包括尿皮质素（UCN），其也由胎盘和子宫内组织表达。在人类妊娠期间，CRH似乎靶向多个胎儿-母体组织，包括子宫肌层，暗示CRH在调节从松弛到主动子宫收缩的转变。CRH的子宫肌层作用是通过一个广泛的特异性G蛋白偶联膜结合受体网络介导的。这些受体具有各种功能特性，取决于受体亚型、激动剂激活特定信号级联的能力和妊娠阶段。此外，它们的功能依赖于通过信号级联之间的通信的其他细胞内信号，这表明CRH和其他CRH样肽在妊娠和分娩期间的潜在多重作用。本文就CRH和UCN及其子宫肌层受体在妊娠、分娩和分娩过程中的作用作一综述。
The mechanism of human labor remains a scientific enigma. Corticotropin-releasing hormone (CRH), a hypothalamic peptide that controls the response of the body to stress and which is also produced by the placenta and intrauterine tissues during pregnancy is potentially involved in the onset of labor. CRH is part of a family of mammalian peptides that includes the urocortins (UCNs), which are also expressed by the placenta and intrauterine tissues. During human pregnancy, CRH appears to target multiple feto-maternal tissues, including the myometrium, implicating CRH in the regulation of the transition from relaxation to active uterine contractions. The myometrial actions of CRH are mediated via a wide network of specific G-protein coupled membrane-bound receptors. These receptors have various functional properties, depending on the receptor subtype, the ability of agonists to activate specific signalling cascades and the stage of pregnancy. In addition, their function is dependant upon other intracellular signals via communication between signalling cascades, suggesting potential multiple roles of CRH and other CRH-like peptides during pregnancy and labor. This review will provide the current concepts about the role of CRH and UCNs and their myometrial receptors during pregnancy, labor and delivery.