Clinical significance of lipoprotein size and risk for coronary atherosclerosis.
Clinical significance of lipoprotein size and risk for coronary atherosclerosis.
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DOI：
10.1093/clinchem/41.1.147
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发表时间：
1995
影响因子：
9.3
通讯作者：
P. Roheim;B. Asztalos
中科院分区：
文献类型：
--
作者：
P. Roheim;B. Asztalos
冠心病与脂蛋白的大小和组成之间的相关性是有充分证据的。在低密度脂蛋白(LDL)家族中，较小的低密度脂蛋白颗粒与冠心病风险增加有关。这些颗粒还增加了载脂蛋白B的含量。这些细小的低密度脂蛋白颗粒的出现是血浆脂蛋白代谢复杂变化的表现。低密度脂蛋白的大小受遗传、内分泌和环境因素的影响。在高密度脂蛋白(HDL2)家族中，较大的HDL2颗粒减少与冠心病有关。根据载脂蛋白的组成，高密度脂蛋白也可分为仅含脂蛋白(Lp)A-I的颗粒以及含有LPA-I和LPA-II的颗粒。大多数研究表明，只有LPA-I的颗粒浓度在冠心病中降低。高密度脂蛋白在循环中重塑，这种重塑在采血后在体外继续进行。因此，适当保存血液样本是必要的。
Correlation between coronary heart disease and lipoprotein size and composition is well documented. Within the low-density lipoprotein (LDL) family the small LDL particles are associated with increased risk of coronary heart disease. These particles also have increased apolipoprotein (apo) B content. The appearance of these small LDL particles is the manifestation of complex alteration of plasma lipoprotein metabolism. The LDL size is influenced by genetic, endocrine, and environmental factors. Within the high-density lipoprotein (HDL) family the decrease of larger HDL2 particles is associated with coronary heart disease. HDLs can also be separated according to their apoprotein composition into particles containing lipoprotein (Lp)A-I only and particles containing LpA-I and LpA-II. Most studies have shown that the concentration of LpA-I-only particles decreases in coronary heart disease. HDLs are remodeled in the circulation and this remodeling continues in vitro after the blood is taken. Therefore adequate preservation of blood samples is necessary.