Cognitive and behavioral outcomes of epileptic syndromes: Implications for education and clinical practice
Cognitive and behavioral outcomes of epileptic syndromes: Implications for education and clinical practice
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DOI：
10.1111/j.1528-1167.2006.00709.x
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发表时间：
2006-01-01
期刊：
影响因子：
5.6
通讯作者：
Besag, Frank M. C.
中科院分区：
文献类型：
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作者：
Besag, Frank M. C.
癫痫儿童的教育和社会进步不仅取决于癫痫发作的控制，还取决于认知和行为因素。儿童期和青春期的各种癫痫综合征在认知和行为结果方面有很大的不同。患有韦斯特综合征的婴儿和患有德拉维综合征(婴儿期严重的肌阵挛癫痫)的儿童将有长期的认知和行为问题。Lennox-Gastaut综合征在这方面的预后通常也很差。患有Landau-Kleffner综合征的儿童预后各不相同，一些恢复了语言能力，另一些则有永久性的语言障碍。良性儿童癫痫伴中央-颞叶棘波现在被认为与Landau-Kleffner综合征相同：轻度病例几乎没有认知或行为问题，但其他人可能有相当严重的困难。青少年肌阵挛癫痫患者可能具有额叶受损的特征。与儿童期和青春期癫痫综合征相关的教育和社会障碍非常重要，但很少有出色的研究以此为主题。这些损害并不一定是永久性的，而且这些综合征中至少有一些的认知和行为结果很有可能受到早期有效的抗癫痫药物治疗或手术的极大影响。
The educational and social progress of a child with epilepsy depends not only on seizure control but also on cognitive and behavioral factors. The various epilepsy syndromes of childhood and adolescence differ greatly in terms of cognitive and behavioral outcome. A high proportion of babies who have West syndrome and children who have Dravet syndrome (severe myoclonic epilepsy in infancy) will have long-term cognitive and behavioral problems. The Lennox-Gastaut syndrome also often has a poor prognosis in this regard. Children with the Landau-Kleffner syndrome have a variable prognosis, some regain speech and others have permanent speech impairment. Benign childhood epilepsy with centrotemporal spikes is now recognised as lying on a spectrum with the Landau-Kleffner syndrome: mild cases have few if any cognitive or behavioral problems but others may have quite severe difficulties. People with juvenile myoclonic epilepsy may have characteristics suggesting frontal lobe impairment. The educational and social impairments associated with the epilepsy syndromes of childhood and adolescence are of major importance but they have been the subject of remarkably few well-performed studies. The impairments are not always necessarily permanent and it seems highly likely that the cognitive and behavioural outcome of at least some of these syndromes can be influenced greatly by early effective treatment with either antiepileptic medication or surgery.