The effects of low-dose growth hormone in HIV-iInfected men with fat accumulation: A pilot study
The effects of low-dose growth hormone in HIV-iInfected men with fat accumulation: A pilot study
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DOI：
10.1086/422725
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发表时间：
2004-09-01
影响因子：
11.8
通讯作者：
Schambelan, M
中科院分区：
文献类型：
--
作者：
Lo, JC;Mulligan, K;Schambelan, M
药物剂量的生长激素(GH)减少了HIV相关的脂肪堆积，但可能会恶化葡萄糖代谢。我们研究了低剂量生长激素(每天1毫克)对有脂肪堆积的艾滋病毒感染男性的影响，发现这种治疗减少了总脂肪，增加了瘦体重，而葡萄糖耐量或胰岛素敏感性没有明显变化。内脏脂肪组织(VAT)水平在整个组中没有显著变化，尽管VAT水平在基线水平较高的患者中有所下降。
Pharmacologic doses of growth hormone (GH) reduce HIV-associated fat accumulation but may worsen glucose metabolism. We investigated the effects of a low dose of GH (1 mg per day) in HIV-infected men with fat accumulation and found that such treatment reduced total fat and increased lean body mass without significant changes in glucose tolerance or insulin sensitivity. Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline.