AN ASSESSMENT OF THE CAUSES OF THE CESIUM EFFECT
AN ASSESSMENT OF THE CAUSES OF THE CESIUM EFFECT
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DOI：
10.1021/jo00228a015
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发表时间：
1987-09-18
影响因子：
3.6
通讯作者：
KELLOGG, RM
中科院分区：
文献类型：
--
作者：
DIJKSTRA, G;KRUIZINGA, WH;KELLOGG, RM
Cesium alkanoates (chiefly the propionate) have been investigated for their solubility, nucleophilic reactivity, and degree of ion pairing in dimethylformamide (DMF) and, in some cases, dimethyl sulfoxide (DMSO) solutions. 133Cs NMR has been used toestablish the degree of ion pairing. From the data obtained it is concluded that the cesium ion is virtually completely solvated and that the carboxylates are essentially free and highly reactive. The consequences of this effect on macrocyclization by means of nucleophilic substitution are discussed.
