Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor
Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor
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DOI：
10.1016/s0006-8993(99)01208-1
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发表时间：
1999-04-24
期刊：
影响因子：
2.9
通讯作者：
Maier, SF
中科院分区：
文献类型：
--
作者：
Grahn, RE;Will, MJ;Maier, SF
中缝背核（dorsal raphe nucleus，DRN）及其能神经末梢被认为是暴露于不可控制的应激源产生不良逃避反应和增强条件性恐惧表达的神经基质的一部分。这种应激暴露被认为选择性地激活DRN多巴胺能神经元，从而使它们对进一步的输入短暂敏感。由于这种致敏状态，行为测试程序被认为会在控制这些行为的大脑区域引起过量的多巴胺能活动。目前的研究进行调查活动后，DRN暴露于逃避和轭，不可避免的尾震。神经活动的特点是使用免疫组织化学检测立即早期基因产物Fos的DRN中的降钙素免疫反应细胞。不可避免的尾休克导致更大的多巴胺能神经活动比逃避尾休克，支持的假设，即不可控的应激优先激活DRN的多巴胺能神经元。(C)1999 Elsevier Science B.V.保留所有权利。
The dorsal raphe nucleus (DRN) and its serotonergic terminal regions have been suggested to be part of the neural substrate by which exposure to uncontrollable stressors produces poor escape responding and enhanced conditioned fear expression. Such stressor exposure is thought to selectively activate DRN serotonergic neurons in such a way as to render them transiently sensitized to further input. As a result of this sensitized state, behavioral testing procedures are thought to cause excess serotonergic activity in brain regions that control these behaviors. The present studies were conducted to investigate activity in the DRN following exposure to escapable and yoked, inescapable tailshock. Neural activity was characterized using immunohistochemistry to detect the immediate early gene product Fos in serotonin-immunoreactive cells in the DRN. Inescapable tailshock led to greater serotonergic neural activity than did escapable tailshock, supporting the hypothesis that uncontrollable stressors preferentially activate serotonergic neurons in the DRN. (C) 1999 Elsevier Science B.V. All rights reserved.