Primary Epitheliotropic Intestinal T-cell Lymphoma in a Horse
Primary Epitheliotropic Intestinal T-cell Lymphoma in a Horse
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马原发性上皮性肠 T 细胞淋巴瘤
DOI：
10.1177/104063870201400209
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发表时间：
2002
影响因子：
1.5
通讯作者：
V. Valli
中科院分区：
文献类型：
--
作者：
M. Pinkerton;K. Bailey;K. K. Thomas;T. E. Goetz;V. Valli
A 17-year-old Quarterhorse gelding with a clinical diagnosis of protein-losing enteropathy was submitted for necropsy following a 4–5-month duration of weight loss, decreased appetite, and hypoproteinemia. Gross findings included multiple 1–2-cm diameter ulcers on the luminal surfaces of the duodenum and ileum. Histologic examination revealed individual large, round cells infiltrating much of the mucosal epithelium of the duodenum, jejunum, ileum, and colon in addition to multifocal areas of ulceration. Similar round cells infiltrated Brunner's glands and expanded the submucosa beneath the foci of ulceration. Immunohistochemical staining indicated the round cell population was of T-lymphocyte origin. Several features of this equine neoplasm bear similarities to enteropathy-associated T-cell lymphoma in humans.
