Immune Responses Regulated by Cannabidiol
Immune Responses Regulated by Cannabidiol
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DOI：
10.1089/can.2018.0073
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发表时间：
2020-03-01
影响因子：
3.8
通讯作者：
Kaplan, Barbara L. F.
中科院分区：
文献类型：
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作者：
Nichols, James M.;Kaplan, Barbara L. F.
大麻二酚（CBD）作为Epidiolex((R)) （GW Pharmaceuticals）最近被美国食品和药物管理局（FDA）批准用于治疗2岁及以上患者的罕见癫痫。随着许多州越来越多的社会接受娱乐性大麻和CBD油用于假定的医疗用途，接触CBD的人数正在增加，尽管其所有的生物效应尚不清楚。CBD的抗炎和免疫抑制能力就是这样一个例子，所以本文的目的是总结CBD在免疫系统中的作用和机制。它包括考虑识别CBD作用的受体的报告，因为“CBD受体”，如果存在一个单独的受体，还没有被明确地确定为无数的免疫系统效应。然后综述了免疫系统和自身免疫模型的体内和体外效应，重点是实验性自身免疫性脑脊髓炎，并以识别知识空白结束。结论：总体而言，数据压倒性地支持CBD具有免疫抑制作用的观点，其机制包括直接抑制各种免疫细胞类型的激活，诱导细胞凋亡，促进调节细胞，从而控制其他免疫细胞靶点。
Introduction: Cannabidiol (CBD) as Epidiolex((R)) (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance of recreational cannabis and CBD oil for putative medical use in many states, the exposure to CBD is increasing, even though all of its biological effects are not understood. Once such example is the ability of CBD to be anti-inflammatory and immune suppressive, so the purpose of this review is to summarize effects and mechanisms of CBD in the immune system. It includes a consideration of reports identifying receptors through which CBD acts, since the "CBD receptor," if a single one exists, has not been definitively identified for the myriad immune system effects. The review then provides a summary of in vivo and in vitro effects in the immune system, in autoimmune models, with a focus on experimental autoimmune encephalomyelitis, and ends with identification of knowledge gaps. Conclusion: Overall, the data overwhelmingly support the notion that CBD is immune suppressive and that the mechanisms involve direct suppression of activation of various immune cell types, induction of apoptosis, and promotion of regulatory cells, which, in turn, control other immune cell targets.