Multiple effects of GDF-5 deficiency on skeletal tissues: Implications for therapeutic bioengineering
Multiple effects of GDF-5 deficiency on skeletal tissues: Implications for therapeutic bioengineering
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DOI：
10.1023/b:abme.0000017549.57126.51
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发表时间：
2004-03-01
影响因子：
3.8
通讯作者：
Mikic, B
中科院分区：
文献类型：
--
作者：
Mikic, B
生长/分化因子（GDF）是已知在骨骼系统中发挥多种作用的高度保守的骨形态发生蛋白（BMP）信号传导分子组的亚家族。特别地，基于这些蛋白质的C-末端信号传导区中的高度氨基酸序列同源性，将GDF 5、6和7分组在一起。在这些GDF中具有功能无效突变的几种天然存在的和工程改造的小鼠模型的存在导致了对GDF缺乏对骨骼组织和过程的影响的各种调查。迄今为止，这些模型的最佳特征是GDF-5缺陷的短足动物（bp）小鼠。在本文中，一个全面的审查的研究进行bp小鼠的努力，以阐明潜在的治疗生物工程应用GDF-5的影响。根据迄今为止的现有证据，GDF-5可能有望作为一种可能的治疗剂，用于肌腱/韧带修复以及椎间盘退变、软骨修复和骨增强，尽管需要进一步详细的介入研究来研究这些潜在的应用。
The growth/differentiation factors (GDFs) are a subfamily of the highly conserved group of bone morphogenetic protein (BMP) signaling molecules known to play a diverse set of roles in the skeletal system. GDFs 5, 6, and 7 in particular have been grouped together on the basis of the high degree of amino acid sequence homology in the C-terminal signaling region of these proteins. The existence of several naturally occurring and engineered mouse models with functional null mutations in these GDFs has led to a variety of investigations into the effects of GDF deficiency on skeletal tissues and processes. The best characterized of these models to date is the GDF-5-deficient brachypod (bp) mouse. In this paper, a comprehensive review of the studies performed on the bp mouse is provided in an effort to elucidate implications for potential therapeutic bioengineering applications using GDF-5. On the basis of the available evidence to date, GDF-5 may hold promise as a possible therapeutic agent for applications involving tendon/ligament repair as well as perhaps intervertebral disk degeneration, cartilage repair, and bone augmentation, although further detailed interventional studies will be required to investigate these potential applications.