Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways.
Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways.
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DOI：
10.1016/b978-0-12-385233-5.00002-7
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发表时间：
2010
影响因子：
--
通讯作者：
Stanger, Ben Z.
中科院分区：
文献类型：
--
作者：
Rhim, Andrew D.;Stanger, Ben Z.
胚胎发育标志着哺乳动物生命周期中组织生长和形态发生的高峰期。在成年动物中，细胞增殖和运动的许多途径相对静止，但在癌变过程中被重新激活。这种现象在胰腺癌中得到了详细的记录，其中详细的遗传研究和强大的小鼠模型使研究人员能够测试各种发育信号在癌症进展中的作用。在本章中，我们回顾了目前关于胰腺发育过程中信号通路的知识，并有证据表明，发育重要信号的重新激活对这种难治性恶性肿瘤的发病机制至关重要。
Embryonic development marks a period of peak tissue growth and morphogenesis in the mammalian lifecycle. Many of the pathways that underlie cell proliferation and movement are relatively quiescent in adult animals but become reactivated during carcinogenesis. This phenomenon has been particularly well documented in pancreatic cancer, where detailed genetic studies and a robust mouse model have permitted investigators to test the role of various developmental signals in cancer progression. In this chapter, we review current knowledge regarding the signaling pathways that act during pancreatic development and the evidence that the reactivation of developmentally important signals is critical for the pathogenesis of this treatment-refractory malignancy.