The DCC protein and prognosis in colorectal cancer
The DCC protein and prognosis in colorectal cancer
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DOI：
10.1056/nejm199612053352303
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发表时间：
1996-12-05
影响因子：
158.5
通讯作者：
Summerhayes, IC
中科院分区：
文献类型：
--
作者：
Shibata, D;Reale, MA;Summerhayes, IC
背景染色体18q等位基因缺失预示II期结直肠癌患者预后不良。虽然这种等位基因缺失导致的特定基因失活尚未阐明，但DCC（在结直肠癌中缺失）基因是一个候选者。我们研究了DCC蛋白在肿瘤细胞中的表达是否是结直肠癌的预后标志物。方法对132例II期或III期结直肠癌患者的石蜡包埋标本进行免疫组化检测。考克斯比例风险模型被用来调整协变量，包括年龄，性别，肿瘤部位，肿瘤分化程度，并使用辅助therapy.Results DCC的表达是一个强有力的阳性预测因子，在II期和III期结直肠癌的生存。在肿瘤表达DCC的II期患者中，5年生存率为94.3%，而在DCC阴性肿瘤患者中，5年生存率为61.6%（P
Background Allelic loss of chromosome 18q predicts a poor outcome in patients with stage II colorectal cancer. Although the specific gene inactivated by this allelic loss has not been elucidated, the DCC (deleted in colorectal cancer) gene is a candidate. We investigated whether the expression of the DCC protein in tumor cells is a prognostic marker in colorectal carcinoma.Methods The expression of DCC was evaluated immunohistochemically in 132 paraffin-embedded samples from patients with curatively resected stage II or III colorectal carcinomas. The Cox proportional-hazards model was used to adjust for covariates including age, sex, tumor site, degree of tumor differentiation, and use of adjuvant therapy.Results The expression of DCC was a strong positive predictive factor for survival in both stage II and stage III colorectal carcinomas. In patients with stage II disease whose tumors expressed DCC, the five-year survival rate was 94.3 percent, whereas in patients with DCC-negative tumors, the survival rate was 61.6 percent (P