New Breakthroughs in Understanding the Role of Functional Interactions between the Neocortex and the Claustrum
New Breakthroughs in Understanding the Role of Functional Interactions between the Neocortex and the Claustrum
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DOI：
10.1523/jneurosci.1837-17.2017
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发表时间：
2017-11-08
影响因子：
5.3
通讯作者：
Citri, Ami
中科院分区：
文献类型：
--
作者：
Brown, Solange P.;Mathur, Brian N.;Citri, Ami
新皮质的几乎所有区域都与屏蔽体相连，屏蔽体是位于新皮质和纹状体之间的一个核，但皮质屏蔽层和屏蔽层的连接功能仍然很不清楚。由于目前正在进行对新皮质进行建模的主要努力，将皮质-屏蔽层系统纳入皮质功能理论变得越来越重要。这次小型研讨会是由最近的一系列研究推动的，这些研究引发了关于屏频回路功能的新假说。解剖学、超微结构和功能研究表明，屏状核与前额叶皮质高度相关，提示在高级认知加工中起重要作用，并且皮质屏蔽层系统的组织结构不同于通常用于描述皮质丘脑系统的驱动/调节框架。最近的发现支持在检测新的感觉刺激、引导注意力和设定行为状态方面的作用，这是2017年神经科学学会年会上的小型研讨会的主题。
Almost all areas of the neocortex are connected with the claustrum, a nucleus located between the neocortex and the striatum, yet the functions of corticoclaustral and claustrocortical connections remain largely obscure. As major efforts to model the neocortex are currently underway, it has become increasingly important to incorporate the corticoclaustral system into theories of cortical function. This Mini-Symposium was motivated by a series of recent studies which have sparked new hypotheses regarding the function of claustral circuits. Anatomical, ultrastructural, and functional studies indicate that the claustrum is most highly interconnected with prefrontal cortex, suggesting important roles in higher cognitive processing, and that the organization of the corticoclaustral system is distinct from the driver/modulator framework often used to describe the corticothalamic system. Recent findings supporting roles in detecting novel sensory stimuli, directing attention and setting behavioral states, were the subject of the Mini-Symposium at the 2017 Society for Neuroscience Annual Meeting.