High-speed ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy
High-speed ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy
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DOI：
10.1001/archopht.125.6.775
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发表时间：
2007-06-01
影响因子：
--
通讯作者：
Fujimoto, James G.
中科院分区：
文献类型：
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作者：
Rodriguez-Padilla, Julio A.;Hedges, Thomas R., III;Fujimoto, James G.
目的：为了比较结构的变化，在视网膜上看到的高速超高分辨率光学相干断层扫描（hsUHR-OCT）与多焦视网膜电图（mfERG）和自动视野的患者接受hydroxycloquine.Methods：15例接受hydroxycloquine进行了临床评估与hsUHR-OCT，mfERG，和自动视野。六个年龄匹配的主题与hsUHR-OCT成像，并作为controls.Results：独特的不连续性的perifoveal感光内段/外段交界处和变薄的外核层被认为与hsUHR-OCT在轻度视网膜毒性作用的患者。在更晚期的病例中观察到进展至内段/外段连接完全丧失和外段水平的高散射。mfERG异常与hsUHR-OCT结果相关。无症状患者hsUHR-OCT和mfERG结果正常。结论：在接受羟氯喹的患者中，hsUHR-OCT显示了中心凹周围感光细胞内段/外段连接的明显异常，这些患者也有症状，自动视野和mfERG异常。
Objectives: To compare structural changes in the retina seen on high-speed ultra-high-resolution optical coherence tomography ( hsUHR-OCT) with multifocal electroretinography ( mfERG) and automated visual fields in patients receiving hydroxychloroquine.Methods: Fifteen patients receiving hydroxychloroquine were evaluated clinically with hsUHR-OCT, mfERG, and automated visual fields. Six age-matched subjects were imaged with hsUHR-OCT and served as controls.Results: Distinctive discontinuity of the perifoveal photoreceptor inner segment/outer segment junction and thinning of the outer nuclear layer were seen with hsUHR-OCT in patients with mild retinal toxic effects. Progression to complete loss of the inner segment/outer segment junction and hyperscattering at the outer segment level were seen in more advanced cases. The mfERG abnormalities correlated with the hsUHR-OCT findings. Asymptomatic patients had normal hsUHR-OCT and mfERG results.Conclusion: Distinctive abnormalities in the perifoveal photoreceptor inner segment/outer segment junction were seen on hsUHR-OCT in patients receiving hydroxychloroquine who also were symptomatic and had abnormalities on automated visual fields and mfERG.